- Promote human dermal fibroblast proliferation, a primary cell type that makes up the skin.1,2
- Increase proliferation and migration of human keratinocytes, a primary cell type found in skin, as well as stimulate production of collagen and a variety of growth factors and cytokines involved in cell migration, increased blood flow, vascularization, and cell renewal.3
- Increase collagen and hyaluronic acid synthesis in human dermal fibroblasts, proteins associated with healthy, youthful skin, skin remodeling, and healing.4
- Reverse the damaging effects of UV radiation, fight wrinkle formation, increase cell proliferation, increase collagen production, and decrease expression of MMP1, a gene linked to scar formation.5
- Inhibit proliferation of melanoma cells (skin cancer), protect skin cells from chemical induced oxidative stress, and boost collagen synthesis and cell motility, showing that these factors may help fight skin cancer and the effects of photoaging.6,7
- Reduce healing time after laser resurfacing and catalyze production of collagen and elastin.8
As we age, there is a natural decrease in the levels of growth factors and cytokines that maintain the youthful appearance of our skin. Many of these factors are abundantly produced by our stem cells, which also decrease in number over the years. FACTORFIVE helps your skin by providing human stem cell derived factors to boost and replace the factors that typically diminish with time. By providing these missing factors, the skin cells begin to act like they did when they were younger, providing an increase in collagen, elastin, and extra cellular matrix proteins that support skin firmness.1,3,4
It’s very simple, you’re not a plant. Human derived growth factors work best on human skin. FACTORFIVE’s human stem cell growth factors work like a lock & key with the receptors on your skin cells, promoting an increase in collagen, hyaluronic acid, elastin, and other beneficial skin proteins, which lead to a healthy and youthful appearance. 4,5,6 While some plant extracts do contain vitamins and antioxidants that can help your skin, they simply do not compare to the powerful cytokines and growth factors produced by human stem cells.
FACTORFIVE does not source stem cells from unethical sources. We only use fresh human adipose derived stem cells (ADSCs) that have been acquired with consent from lipoaspirate, the fat from liposuction that is typically discarded after surgery. Also, our human ADSCs have been through multiple, rigorous safety and efficacy checks. No embryos, human eggs (oocytes), bone marrow, or other controversial tissues are used to produce FACTORFIVE.
Human skin is made up of a variety of cell types that work together to maintain elasticity of the skin and protect you from external sources of damage. While fibroblasts are a primary cell type that makes up skin, there are also keratin producing keratinocytes, melanocytes (which give the skin its pigment), fat cells (aka adipocytes), as well as a variety of support cells that feed the layers of the skin with blood and nutrients. Adipose derived stem cells (ADSCs) are involved in catalyzing healing within the body and are capable of turning into all the cell types that make up the skin. Fibroblasts, on the other hand, are typically sourced from fetal foreskin obtained during circumcision and only produce a fraction of the beneficial factors that ADSCs produce. While fibroblast conditioned media is capable of providing some beneficial factors, FACTORFIVE provides a wider, more complete profile of healing factors to support all the cell types the make up your skin. 1,3,4,5,7
FACTORFIVE contains proteins produced by human adipose derived stem cells, not the cells themselves. These proteins are essentially the same for all human cells, so there are no individual compatibility issues or necessity to use your own cells.
FACTORFIVE does not contain any cells, only proteins derived from cells. The stem cells are carefully removed and filtered out through a multistep process, leaving only purified & concentrated stem cell derived factors in the final product.
We designed FACTORFIVE to be the the best skin serum on the market. We did not aim to be marginally better, we formulated FACTORFIVE from the ground up to provide the best ingredients from the best sources so that you could benefit from the latest in skin rejuvenation technology without having to compromise or purchase multiple products. While stem cell derived factors are the primary active ingredient in FACTORFIVE, we have also added a selection of vitamins, antioxidants, peptides, and skin remodeling support factors to ensure that you get immediate and long term benefits as you continue to regularly use FACTORFIVE.
FACTORFIVE is completely safe when used as directed. We have tested it under the recommended conditions for supporting healthy, normal skin. To many people, it seems intuitive that growth factors may increase the risk of cancer. However, there is no scientific evidence linking cancer to growth factor products. In fact, there is a growing body of research that shows that topically applied ADSC growth factors may inhibit the growth of skin cancer cells (melanoma) and protect your skin.6,7
Since FACTORFIVE is essentially replacing or boosting the factors that your skin is no longer producing, we recommend regular and continuous use of FACTORFIVE to maintain the benefits to your skin.
- Kim WS, Park BS, Sung JH, Yang JM, Park SB, Kwak SJ, Park JS. Wound healing effect of adipose-derived stem cells: a critical role of secretory factors on human dermal fibroblasts. J Dermatol Sci. 2007 Oct;48(1):15-24. Epub 2007 Jul 23. PubMed PMID: 17643966. ↗
- Wong VW, Gurtner GC, Longaker MT. Wound healing: a paradigm for regeneration. Mayo Clin Proc. 2013 Sep;88(9):1022-31. doi: 10.1016/j.mayocp.2013.04.012. ↗
- Moon KM, Park YH, Lee JS, Chae YB, Kim MM, Kim DS, Kim BW, Nam SW, Lee JH. The effect of secretory factors of adipose-derived stem cells on human keratinocytes. Int J Mol Sci. 2012;13(1):1239-57. doi: 10.3390/ijms13011239. Epub 2012 Jan 23. ↗
- Jung H, Kim HH, Lee DH, Hwang YS, Yang HC, Park JC. Transforming growth factor-beta 1 in adipose derived stem cells conditioned medium is a dominant paracrine mediator determines hyaluronic acid and collagen expression profile. Cytotechnology. 2011 Jan;63(1):57-66. doi: 10.1007/s10616-010-9327-4. Epub 2011 Jan 4. ↗
- Kim WS, Park BS, Park SH, Kim HK, Sung JH. Antiwrinkle effect of adipose-derived stem cell: activation of dermal fibroblast by secretory factors. J Dermatol Sci. 2009 Feb;53(2):96-102. doi: 10.1016/j.jdermsci.2008.08.007. Epub 2008 Oct 1. ↗
- Kim WS, Park BS, Sung JH. Protective role of adipose-derived stem cells and their soluble factors in photoaging. Arch Dermatol Res. 2009 Jun;301(5):329-36. doi: 10.1007/s00403-009-0951-9. Epub 2009 Apr 26. ↗
- Kim WS, Park BS, Sung JH. The wound-healing and antioxidant effects of adipose-derived stem cells. Expert Opin Biol Ther. 2009 Jul;9(7):879-87. doi: 10.1517/14712590903039684. ↗
- Zhou BR, Xu Y, Guo SL, Xu Y, Wang Y, Zhu F, Permatasari F, Wu D, Yin ZQ, Luo D. The effect of conditioned media of adipose-derived stem cells on wound healing after ablative fractional carbon dioxide laser resurfacing. Biomed Res Int. 2013;2013:519126. doi: 10.1155/2013/519126. Epub 2013 Dec 4. ↗